A salient concept in biocompatible dentistry is that, everything implanted within/around a tooth constitutes a systematic exposure, whose effects have to be properly accounted for. Dental proponents face two main challenges in restoring the tooth function and eliminating disease. First, they have to make the right choices of synthetic items, based on their restorative and aesthetic functions while at the same time not ignoring individual reactions/allergies. The second challenge is the reduction of pathogens, wherein toxicology comes into effect. For the above mentioned concerns, the medical device domain has transcended its biocompatibility testing methodologies, further from the archaic cytotoxicity, carcinogenicity and sensitization tests. The latest safety assessment guide is the International Organization of Standardization (ISO) 10993 standard, a 17 part standard that facilitates thorough customized evaluation, which includes tests for chronic/sub-chronic toxins, circulatory toxins, characterization and toxicity of breakdown leachates. Various dentistry products have been made available to the market under the aforementioned rule, and they include mercury amalgam, endoscopic implants together with seventh generation bonding agents.